ATM and KAT5 safeguard replicating chromatin against formaldehyde damage

Many carcinogens damage both DNA and protein constituents of chromatin, and it is unclear how cells respond to this compound injury. We examined activation of the main DNA damage-responsive kinase ATM and formation of DNA double-strand breaks (DSB) by formaldehyde (FA) that forms histone adducts and...

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Detalles Bibliográficos
Autores principales: Ortega-Atienza, Sara, Wong, Victor C., DeLoughery, Zachary, Luczak, Michal W., Zhitkovich, Anatoly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705693/
https://www.ncbi.nlm.nih.gov/pubmed/26420831
http://dx.doi.org/10.1093/nar/gkv957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705693/
https://www.ncbi.nlm.nih.gov/pubmed/26420831
http://dx.doi.org/10.1093/nar/gkv957

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