DNA double-strand breaks with 5′ adducts are efficiently channeled to the DNA2-mediated resection pathway

DNA double-strand breaks (DSBs) with 5′ adducts are frequently formed from many nucleic acid processing enzymes, in particular DNA topoisomerase 2 (TOP2). The key intermediate of TOP2 catalysis is the covalent complex (TOP2cc), consisting of two TOP2 subunits covalently linked to the 5′ ends of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Tammaro, Margaret, Liao, Shuren, Beeharry, Neil, Yan, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705695/
https://www.ncbi.nlm.nih.gov/pubmed/26420828
http://dx.doi.org/10.1093/nar/gkv969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705695/
https://www.ncbi.nlm.nih.gov/pubmed/26420828
http://dx.doi.org/10.1093/nar/gkv969

Ejemplares similares