Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP(2))

Sperm-specific phospholipase C-ζ (PLCζ) is widely considered to be the physiological stimulus that triggers intracellular Ca(2+) oscillations and egg activation during mammalian fertilization. Although PLCζ is structurally similar to PLCδ1, it lacks a pleckstrin homology domain, and it remains uncle...

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Detalles Bibliográficos
Autores principales: Nomikos, Michail, Sanders, Jessica R., Parthimos, Dimitris, Buntwal, Luke, Calver, Brian L., Stamatiadis, Panagiotis, Smith, Adrian, Clue, Matthew, Sideratou, Zili, Swann, Karl, Lai, F. Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Lipids
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705952/
https://www.ncbi.nlm.nih.gov/pubmed/26429913
http://dx.doi.org/10.1074/jbc.M115.658443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705952/
https://www.ncbi.nlm.nih.gov/pubmed/26429913
http://dx.doi.org/10.1074/jbc.M115.658443

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