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Dietary zinc supplementation increased TNFα and IL1β-induced RANKL expression, resulting in a decrease in bone mineral density in rats

We investigated the effect of dietary zinc supplementation on bone metabolism in rats. Four-week-old male Wistar rats were fed a 30.0 mg zinc/kg diet (C), a 300.0 mg zinc/kg diet (HZ) or a 3,000.0 mg zinc/kg diet (EZ) for 4 weeks. The zinc content of the femur gradually increased in accordance with...

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Detalles Bibliográficos
Autores principales: Suzuki, Takako, Katsumata, Shin-ichi, Matsuzaki, Hiroshi, Suzuki, Kazuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706095/
https://www.ncbi.nlm.nih.gov/pubmed/26798197
http://dx.doi.org/10.3164/jcbn.15-71