Josephin Domain Structural Conformations Explored by Metadynamics in Essential Coordinates

The Josephin Domain (JD), i.e. the N-terminal domain of Ataxin 3 (At3) protein, is an interesting example of competition between physiological function and aggregation risk. In fact, the fibrillogenesis of Ataxin 3, responsible for the spinocerebbellar ataxia 3, is strictly related to the JD thermod...

Descripción completa

Detalles Bibliográficos
Autores principales: Deriu, Marco A., Grasso, Gianvito, Tuszynski, Jack A., Gallo, Diego, Morbiducci, Umberto, Danani, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706304/
https://www.ncbi.nlm.nih.gov/pubmed/26745628
http://dx.doi.org/10.1371/journal.pcbi.1004699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706304/
https://www.ncbi.nlm.nih.gov/pubmed/26745628
http://dx.doi.org/10.1371/journal.pcbi.1004699

Ejemplares similares