Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML

Rapid remission of MDS/AML may be induced with Decitabine; however, significant megakaryocyte expansion and subsequent thrombocytosis may occur. Decitabine‐mediated reversion of the MDS to benign ET via hypomethylation of JAK/STAT pathway repressors is one potential mechanism to explain this observe...

Descripción completa

Detalles Bibliográficos
Autores principales: Horton, Joshua D., Arbini, Arnaldo A., Perle, Mary Ann, Raphael, Bruce G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706408/
https://www.ncbi.nlm.nih.gov/pubmed/26783435
http://dx.doi.org/10.1002/ccr3.431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706408/
https://www.ncbi.nlm.nih.gov/pubmed/26783435
http://dx.doi.org/10.1002/ccr3.431

Ejemplares similares