Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML

Rapid remission of MDS/AML may be induced with Decitabine; however, significant megakaryocyte expansion and subsequent thrombocytosis may occur. Decitabine‐mediated reversion of the MDS to benign ET via hypomethylation of JAK/STAT pathway repressors is one potential mechanism to explain this observe...

Descripción completa

Detalles Bibliográficos
Autores principales: Horton, Joshua D., Arbini, Arnaldo A., Perle, Mary Ann, Raphael, Bruce G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706408/
https://www.ncbi.nlm.nih.gov/pubmed/26783435
http://dx.doi.org/10.1002/ccr3.431
_version_ 1782409162432446464
author Horton, Joshua D.
Arbini, Arnaldo A.
Perle, Mary Ann
Raphael, Bruce G.
author_facet Horton, Joshua D.
Arbini, Arnaldo A.
Perle, Mary Ann
Raphael, Bruce G.
author_sort Horton, Joshua D.
collection PubMed
description Rapid remission of MDS/AML may be induced with Decitabine; however, significant megakaryocyte expansion and subsequent thrombocytosis may occur. Decitabine‐mediated reversion of the MDS to benign ET via hypomethylation of JAK/STAT pathway repressors is one potential mechanism to explain this observed phenomenon.
format Online
Article
Text
id pubmed-4706408
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-47064082016-01-18 Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML Horton, Joshua D. Arbini, Arnaldo A. Perle, Mary Ann Raphael, Bruce G. Clin Case Rep Case Reports Rapid remission of MDS/AML may be induced with Decitabine; however, significant megakaryocyte expansion and subsequent thrombocytosis may occur. Decitabine‐mediated reversion of the MDS to benign ET via hypomethylation of JAK/STAT pathway repressors is one potential mechanism to explain this observed phenomenon. John Wiley and Sons Inc. 2015-11-15 /pmc/articles/PMC4706408/ /pubmed/26783435 http://dx.doi.org/10.1002/ccr3.431 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Horton, Joshua D.
Arbini, Arnaldo A.
Perle, Mary Ann
Raphael, Bruce G.
Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML
title Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML
title_full Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML
title_fullStr Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML
title_full_unstemmed Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML
title_short Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML
title_sort rapid and robust reversion to essential thrombocythemia on treatment with decitabine in a case of hydroxyurea‐induced t‐mds/aml
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706408/
https://www.ncbi.nlm.nih.gov/pubmed/26783435
http://dx.doi.org/10.1002/ccr3.431
work_keys_str_mv AT hortonjoshuad rapidandrobustreversiontoessentialthrombocythemiaontreatmentwithdecitabineinacaseofhydroxyureainducedtmdsaml
AT arbiniarnaldoa rapidandrobustreversiontoessentialthrombocythemiaontreatmentwithdecitabineinacaseofhydroxyureainducedtmdsaml
AT perlemaryann rapidandrobustreversiontoessentialthrombocythemiaontreatmentwithdecitabineinacaseofhydroxyureainducedtmdsaml
AT raphaelbruceg rapidandrobustreversiontoessentialthrombocythemiaontreatmentwithdecitabineinacaseofhydroxyureainducedtmdsaml

Ejemplares similares