KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas

Lysine deacetylases (KDACs) are enzymes that reverse the post-translational modification of lysine acetylation. Recently, a series of N-acetylthioureas were synthesized and reported to enhance the activity of KDAC8 with a fluorogenic substrate. To determine if the activation was general, we synthesi...

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Detalles Bibliográficos
Autores principales: Toro, Tasha B., Pingali, Subramanya, Nguyen, Thao P., Garrett, Destane S., Dodson, Kyra A., Nichols, Kyara A., Haynes, Rashad A., Payton-Stewart, Florastina, Watt, Terry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706426/
https://www.ncbi.nlm.nih.gov/pubmed/26745872
http://dx.doi.org/10.1371/journal.pone.0146900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706426/
https://www.ncbi.nlm.nih.gov/pubmed/26745872
http://dx.doi.org/10.1371/journal.pone.0146900

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