Cargando…
KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas
Lysine deacetylases (KDACs) are enzymes that reverse the post-translational modification of lysine acetylation. Recently, a series of N-acetylthioureas were synthesized and reported to enhance the activity of KDAC8 with a fluorogenic substrate. To determine if the activation was general, we synthesi...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706426/ https://www.ncbi.nlm.nih.gov/pubmed/26745872 http://dx.doi.org/10.1371/journal.pone.0146900 |