Population pharmacokinetic and exposure–response analysis for trastuzumab administered using a subcutaneous “manual syringe” injection or intravenously in women with HER2-positive early breast cancer

PURPOSE: To characterize the population pharmacokinetics (PKs) of subcutaneous (SC) and intravenous (IV) trastuzumab in early breast cancer (EBC), assess the impact of covariates on trastuzumab PK, and evaluate fixed (nonweight-based) dosing for the SC regimen administrated via handheld syringe. MET...

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Detalles Bibliográficos
Autores principales: Quartino, Angelica L., Hillenbach, Carina, Li, Jing, Li, Hanbin, Wada, Russell D., Visich, Jennifer, Li, Chunze, Heinzmann, Dominik, Jin, Jin Y., Lum, Bert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706584/
https://www.ncbi.nlm.nih.gov/pubmed/26645407
http://dx.doi.org/10.1007/s00280-015-2922-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706584/
https://www.ncbi.nlm.nih.gov/pubmed/26645407
http://dx.doi.org/10.1007/s00280-015-2922-5

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