Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain

Chagas disease, caused by Trypanosoma cruzi, is the main cause of dilated cardiomyopathy in the Americas. Antiparasitic treatment mostly relies on benznidazole (Bzl) due to Nifurtimox shortage or unavailability. Both induce adverse drug effects (ADE) of varied severity in many patients, leading to t...

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Detalles Bibliográficos
Autores principales: Cevey, Ágata Carolina, Mirkin, Gerardo Ariel, Penas, Federico Nicolás, Goren, Nora Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706620/
https://www.ncbi.nlm.nih.gov/pubmed/26862474
http://dx.doi.org/10.1016/j.ijpddr.2015.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706620/
https://www.ncbi.nlm.nih.gov/pubmed/26862474
http://dx.doi.org/10.1016/j.ijpddr.2015.12.001

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