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Discovery of potential ALK inhibitors by virtual screening approach

Crizotinib is an anticancer drug used for the treatment of non-small cell lung cancer. Evidences available suggest that there is a development of an acquired resistance against crizotinib action due to the emergence of several mutations in the ALK gene. It is therefore necessary to develop potent an...

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Detalles Bibliográficos
Autores principales: Kumar, Anish, Shanthi, V., Ramanathan, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706832/
https://www.ncbi.nlm.nih.gov/pubmed/28330089
http://dx.doi.org/10.1007/s13205-015-0336-z