Cargando…

Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes

Regulatory T cells (Tregs) play an important role in preventing effector T-cell (Teff) targeting of self-antigens that can lead to tissue destruction in autoimmune settings, including type 1 diabetes (T1D). Autoimmunity is caused in part by an imbalance between Teff and Tregs. Early attempts to trea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pham, Minh N., von Herrath, Matthias G., Vela, Jose Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707297/ https://www.ncbi.nlm.nih.gov/pubmed/26793191 http://dx.doi.org/10.3389/fimmu.2015.00651

Ejemplares similares

Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential
por: Peakman, Mark, et al.
Publicado: (2010)

A Deeper Look into Type 1 Diabetes – Imaging Immune Responses during Onset of Disease
por: Christoffersson, Gustaf, et al.
Publicado: (2016)

Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study
por: Speake, Cate, et al.
Publicado: (2019)

Non-antigenic and antigenic interventions in type 1 diabetes
por: Rydén, Anna KE, et al.
Publicado: (2013)

APVO210: A Bispecific Anti-CD86-IL-10 Fusion Protein (ADAPTIR™) to Induce Antigen-Specific T Regulatory Type 1 Cells
por: Pellerin, Laurence, et al.
Publicado: (2018)

Overcoming Obstacles in the Development of Antigen-Specific Immunotherapies for Type 1 Diabetes
por: Thomas, Ranjeny, et al.
Publicado: (2021)

Antigenic Challenge Influences Epigenetic Changes in Antigen-Specific T Regulatory Cells
por: Iwaszkiewicz-Grzes, Dorota, et al.
Publicado: (2021)

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?
por: Rodriguez-Calvo, Teresa, et al.
Publicado: (2021)

Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications
por: Sidney, John, et al.
Publicado: (2018)

Effect of low dose IL-2 loaded chitosan nanoparticles on natural killer and regulatory T cell expression in experimentally induced autoimmune type 1 diabetes mellitus
por: Aboelnazar, Salma, et al.
Publicado: (2021)

Can We Learn From Viruses How to Prevent Type 1 Diabetes?: The Role of Viral Infections in the Pathogenesis of Type 1 Diabetes and the Development of Novel Combination Therapies
por: von Herrath, Matthias
Publicado: (2009)

Exploring the Origin and Antigenic Specificity of Maternal Regulatory T Cells in Pregnancy
por: Ahn, Soo Hyun, et al.
Publicado: (2020)

Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation
por: Selck, Claudia, et al.
Publicado: (2021)

Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities
por: Serr, Isabelle, et al.
Publicado: (2021)

Altered Tim-1 and IL-10 Expression in Regulatory B Cell Subsets in Type 1 Diabetes
por: Liu, Yikai, et al.
Publicado: (2021)

Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4(+)CD25(+) Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor
por: Hall, Bruce M., et al.
Publicado: (2021)

Do Natural T Regulatory Cells become Activated to Antigen Specific T Regulatory Cells in Transplantation and in Autoimmunity?
por: Hall, Bruce M., et al.
Publicado: (2013)

Distinct Housing Conditions Reveal a Major Impact of Adaptive Immunity on the Course of Obesity-Induced Type 2 Diabetes
por: Sbierski-Kind, Julia, et al.
Publicado: (2018)

The Development of Immunotherapy Strategies for the Treatment of Type 1 Diabetes
por: Coppieters, Ken, et al.
Publicado: (2018)

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells
por: Dawson, Nicholas A. J., et al.
Publicado: (2017)

Antigen Specific Regulatory T Cells in Kidney Transplantation and Other Tolerance Settings
por: Hu, Min, et al.
Publicado: (2021)

Determining Antigen Specificity of Human Islet Infiltrating T Cells in Type 1 Diabetes
por: Nakayama, Maki, et al.
Publicado: (2019)

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases
por: Graßhoff, Hanna, et al.
Publicado: (2021)

IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production
por: Vigne, Solenne, et al.
Publicado: (2017)

Combination Therapy With an Anti–IL-1β Antibody and GAD65 DNA Vaccine Can Reverse Recent-Onset Diabetes in the RIP-GP Mouse Model
por: Pagni, Philippe P., et al.
Publicado: (2014)

Engineered RBCs Encapsulating Antigen Induce Multi-Modal Antigen-Specific Tolerance and Protect Against Type 1 Diabetes
por: Raposo, Colin J., et al.
Publicado: (2022)

The Type 1 Diabetes Signature: Hardwired to Trigger Inflammation?
por: Coppieters, Ken T., et al.
Publicado: (2014)

Dendritic Cells in the Periphery Control Antigen-Specific Natural and Induced Regulatory T Cells
por: Yamazaki, Sayuri, et al.
Publicado: (2013)

Editorial: Characterisation, functions and roles of antigen-specific regulatory T cells in health and disease
por: Tran, Giang T., et al.
Publicado: (2022)

Conversion of Anergic T Cells Into Foxp3(-) IL-10(+) Regulatory T Cells by a Second Antigen Stimulus In Vivo
por: Thomann, Anna Sophie, et al.
Publicado: (2021)

Low-dose IL-2 improved clinical symptoms by restoring reduced regulatory T cells in patients with refractory rheumatoid arthritis: A randomized controlled trial
por: Wang, Jia, et al.
Publicado: (2022)

A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses
por: Min, Chan-Ki, et al.
Publicado: (2018)

Immunotherapy for the Prevention and Treatment of Type 1 Diabetes: Optimizing the path from bench to bedside
por: Bresson, Damien, et al.
Publicado: (2009)

Viral Trigger for Type 1 Diabetes: Pros and Cons
por: Filippi, Christophe M., et al.
Publicado: (2008)

Recent advances in understanding Type 1 Diabetes
por: Christoffersson, Gustaf, et al.
Publicado: (2016)

Interleukin-10-Producing DC-10 Is a Unique Tool to Promote Tolerance Via Antigen-Specific T Regulatory Type 1 Cells
por: Comi, Michela, et al.
Publicado: (2018)

Metabolic syndrome – Removing roadblocks to therapy: Antigenic immunotherapies()
por: Coppieters, Ken T., et al.
Publicado: (2014)

Potential viral pathogenic mechanism in human type 1 diabetes
por: Schneider, Darius A., et al.
Publicado: (2014)

Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4(+)FOXP3(+) T Regulatory Cells
por: Pohar, Jelka, et al.
Publicado: (2018)

How Thymocyte Deletion in the Cortex May Curtail Antigen-Specific T-Regulatory Cell Development in the Medulla
por: Wang, Chenglong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_popvd4pj8k7tnd4nvdqqosrg04