Inhibition of the RhoA GTPase Activity Increases Sensitivity of Melanoma Cells to UV Radiation Effects

Ultraviolet radiation is the main cause of DNA damage to melanocytes and development of melanoma, one of the most lethal human cancers, which leads to metastasis due to uncontrolled cell proliferation and migration. These phenotypes are mediated by RhoA, a GTPase overexpressed or overactivated in hi...

Descripción completa

Detalles Bibliográficos
Autores principales: Espinha, Gisele, Osaki, Juliana Harumi, Costa, Erico Tosoni, Forti, Fabio Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707346/
https://www.ncbi.nlm.nih.gov/pubmed/26823948
http://dx.doi.org/10.1155/2016/2696952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707346/
https://www.ncbi.nlm.nih.gov/pubmed/26823948
http://dx.doi.org/10.1155/2016/2696952

Ejemplares similares