BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells

Although BRAF(V600E) mutation is associated with adverse clinical outcomes in patients with colorectal cancer (CRC), response and resistance mechanisms for therapeutic BRAF(V600E) inhibitors remains poorly understood. In the present study, we demonstrate that selective BRAF(V600E) inhibition activat...

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Detalles Bibliográficos
Autores principales: Sueda, Toshinori, Sakai, Daisuke, Kawamoto, Koichi, Konno, Masamitsu, Nishida, Naohiro, Koseki, Jun, Colvin, Hugh, Takahashi, Hidekazu, Haraguchi, Naotsugu, Nishimura, Junichi, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Yamamoto, Hirofumi, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707439/
https://www.ncbi.nlm.nih.gov/pubmed/26750638
http://dx.doi.org/10.1038/srep18949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707439/
https://www.ncbi.nlm.nih.gov/pubmed/26750638
http://dx.doi.org/10.1038/srep18949

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