TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy

The pharmacological activation of the cholesterol-binding Translocator Protein (TSPO) leads to an increase of endogenous steroids and neurosteroids determining benefic pleiotropic effects in several pathological conditions, including anxiety disorders. The relatively poor relationship between TSPO l...

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Detalles Bibliográficos
Autores principales: Costa, Barbara, Da Pozzo, Eleonora, Giacomelli, Chiara, Barresi, Elisabetta, Taliani, Sabrina, Da Settimo, Federico, Martini, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707509/
https://www.ncbi.nlm.nih.gov/pubmed/26750656
http://dx.doi.org/10.1038/srep18164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707509/
https://www.ncbi.nlm.nih.gov/pubmed/26750656
http://dx.doi.org/10.1038/srep18164

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