DNA methylation dynamics in mouse preimplantation embryos revealed by mass spectrometry

Following fertilization in mammals, paternal genomic 5-methyl-2′-deoxycytidine (5 mC) content is thought to decrease via oxidation to 5-hydroxymethyl-2′-deoxycytidine (5 hmC). This reciprocal model of demethylation and hydroxymethylation is inferred from indirect, non-quantitative methods. We here r...

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Detalles Bibliográficos
Autores principales: Okamoto, Yoshinori, Yoshida, Naoko, Suzuki, Toru, Shimozawa, Nobuhiro, Asami, Maki, Matsuda, Tomonari, Kojima, Nakao, Perry, Anthony C. F., Takada, Tatsuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707515/
https://www.ncbi.nlm.nih.gov/pubmed/26750605
http://dx.doi.org/10.1038/srep19134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707515/
https://www.ncbi.nlm.nih.gov/pubmed/26750605
http://dx.doi.org/10.1038/srep19134

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