High-Throughput Screening for Internalizing Antibodies by Homogeneous Fluorescence Imaging of a pH-Activated Probe

Antibody-drug conjugates (ADCs) represent a rapidly growing class of biotherapeutics that deliver drugs specifically to target cells by binding of the antibody component to surface receptors. The majority of ADCs require receptor internalization depending on intrinsic features of the specific ADC-an...

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Detalles Bibliográficos
Autores principales: Riedl, Thilo, van Boxtel, Egon, Bosch, Martijn, Parren, Paul W. H. I., Gerritsen, Arnout F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708616/
https://www.ncbi.nlm.nih.gov/pubmed/26518032
http://dx.doi.org/10.1177/1087057115613270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708616/
https://www.ncbi.nlm.nih.gov/pubmed/26518032
http://dx.doi.org/10.1177/1087057115613270

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