Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease

Dysregulated signaling cascades alter energy metabolism and promote cell proliferation and cyst expansion in polycystic kidney disease (PKD). Here we tested whether metabolic reprogramming towards aerobic glycolysis (“Warburg effect”) plays a pathogenic role in male heterozygous Han:SPRD rats (Cy/+)...

Descripción completa

Detalles Bibliográficos
Autores principales: Riwanto, Meliana, Kapoor, Sarika, Rodriguez, Daniel, Edenhofer, Ilka, Segerer, Stephan, Wüthrich, Rudolf P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708993/
https://www.ncbi.nlm.nih.gov/pubmed/26752072
http://dx.doi.org/10.1371/journal.pone.0146654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708993/
https://www.ncbi.nlm.nih.gov/pubmed/26752072
http://dx.doi.org/10.1371/journal.pone.0146654

Ejemplares similares