PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

Mitochondrial Ca(2+) overload is a critical, preceding event in neuronal damage encountered during neurodegenerative and ischemic insults. We found that loss of PTEN-induced putative kinase 1 (PINK1) function, implicated in Parkinson disease, inhibits the mitochondrial Na(+)/Ca(2+) exchanger (NCLX),...

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Detalles Bibliográficos
Autores principales: Kostic, Marko, Ludtmann, Marthe H.R., Bading, Hilmar, Hershfinkel, Michal, Steer, Erin, Chu, Charleen T., Abramov, Andrey Y., Sekler, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709126/
https://www.ncbi.nlm.nih.gov/pubmed/26440884
http://dx.doi.org/10.1016/j.celrep.2015.08.079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709126/
https://www.ncbi.nlm.nih.gov/pubmed/26440884
http://dx.doi.org/10.1016/j.celrep.2015.08.079

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