Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni

BACKGROUND: Schistosoma flatworm parasites cause schistosomiasis, a chronic and debilitating disease of poverty in developing countries. Praziquantel is employed for treatment and disease control. However, its efficacy spectrum is incomplete (less active or inactive against immature stages of the pa...

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Detalles Bibliográficos
Autores principales: Long, Thavy, Neitz, R. Jeffrey, Beasley, Rachel, Kalyanaraman, Chakrapani, Suzuki, Brian M., Jacobson, Matthew P., Dissous, Colette, McKerrow, James H., Drewry, David H., Zuercher, William J., Singh, Rahul, Caffrey, Conor R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709140/
https://www.ncbi.nlm.nih.gov/pubmed/26751972
http://dx.doi.org/10.1371/journal.pntd.0004356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709140/
https://www.ncbi.nlm.nih.gov/pubmed/26751972
http://dx.doi.org/10.1371/journal.pntd.0004356

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