EBNA2 Drives Formation of New Chromosome Binding Sites and Target Genes for B-Cell Master Regulatory Transcription Factors RBP-jκ and EBF1

Epstein-Barr Virus (EBV) transforms resting B-lymphocytes into proliferating lymphoblasts to establish latent infections that can give rise to malignancies. We show here that EBV-encoded transcriptional regulator EBNA2 drives the cooperative and combinatorial genome-wide binding of two master regula...

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Detalles Bibliográficos
Autores principales: Lu, Fang, Chen, Horng-Shen, Kossenkov, Andrew V., DeWispeleare, Karen, Won, Kyoung-Jae, Lieberman, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709166/
https://www.ncbi.nlm.nih.gov/pubmed/26752713
http://dx.doi.org/10.1371/journal.ppat.1005339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709166/
https://www.ncbi.nlm.nih.gov/pubmed/26752713
http://dx.doi.org/10.1371/journal.ppat.1005339

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