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EBNA2 Drives Formation of New Chromosome Binding Sites and Target Genes for B-Cell Master Regulatory Transcription Factors RBP-jκ and EBF1

Epstein-Barr Virus (EBV) transforms resting B-lymphocytes into proliferating lymphoblasts to establish latent infections that can give rise to malignancies. We show here that EBV-encoded transcriptional regulator EBNA2 drives the cooperative and combinatorial genome-wide binding of two master regula...

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Detalles Bibliográficos
Autores principales:	Lu, Fang, Chen, Horng-Shen, Kossenkov, Andrew V., DeWispeleare, Karen, Won, Kyoung-Jae, Lieberman, Paul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709166/ https://www.ncbi.nlm.nih.gov/pubmed/26752713 http://dx.doi.org/10.1371/journal.ppat.1005339

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