Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide, A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, in Rat Stomach

PURPOSE: Acotiamide, a gastroprokinetic agent used to treat functional dyspepsia, is transported to at least two compartments in rat stomach. However, the role of these stomach compartments in pharmacokinetics and pharmacodynamics of acotiamide remains unclear. Thus, the purpose of this study was to...

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Detalles Bibliográficos
Autores principales: Yoshii, Kazuyoshi, Iikura, Minami, Hirayama, Masamichi, Toda, Ryoko, Kawabata, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709389/
https://www.ncbi.nlm.nih.gov/pubmed/26350104
http://dx.doi.org/10.1007/s11095-015-1787-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709389/
https://www.ncbi.nlm.nih.gov/pubmed/26350104
http://dx.doi.org/10.1007/s11095-015-1787-y

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