Targeting TRPM2 Channels Impairs Radiation-Induced Cell Cycle Arrest and Fosters Cell Death of T Cell Leukemia Cells in a Bcl-2-Dependent Manner

Messenger RNA data of lymphohematopoietic cancer lines suggest a correlation between expression of the cation channel TRPM2 and the antiapoptotic protein Bcl-2. The latter is overexpressed in various tumor entities and mediates therapy resistance. Here, we analyzed the crosstalk between Bcl-2 and TR...

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Detalles Bibliográficos
Autores principales: Klumpp, Dominik, Misovic, Milan, Szteyn, Kalina, Shumilina, Ekaterina, Rudner, Justine, Huber, Stephan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709732/
https://www.ncbi.nlm.nih.gov/pubmed/26839633
http://dx.doi.org/10.1155/2016/8026702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709732/
https://www.ncbi.nlm.nih.gov/pubmed/26839633
http://dx.doi.org/10.1155/2016/8026702

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