Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

Accumulating evidence indicates that microglial TLR2 and TLR4 play a significant role in nociception. Experiments were conducted to evaluate the contribution of TLR2 and TLR4 and their adaptor molecules to neuropathy and their ability to amplify opioid effectiveness. Behavioral tests (von Frey'...

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Detalles Bibliográficos
Autores principales: Jurga, Agnieszka M., Rojewska, Ewelina, Piotrowska, Anna, Makuch, Wioletta, Pilat, Dominika, Przewlocka, Barbara, Mika, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709736/
https://www.ncbi.nlm.nih.gov/pubmed/26962463
http://dx.doi.org/10.1155/2016/5238730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709736/
https://www.ncbi.nlm.nih.gov/pubmed/26962463
http://dx.doi.org/10.1155/2016/5238730

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