MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use

In the past two decades, microRNAs have emerged as crucial mediators of organ development and human disease. Here, we discuss their role as drivers or suppressors of the hallmarks of cancer during tumorigenesis and progression, in defining interpatient heterogeneity and the promise of therapeutic ap...

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Detalles Bibliográficos
Autores principales: Nana-Sinkam, S Patrick, Croce, Carlo M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709998/
https://www.ncbi.nlm.nih.gov/pubmed/25315999
http://dx.doi.org/10.1186/s13059-014-0445-8
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author Nana-Sinkam, S Patrick
Croce, Carlo M
author_facet Nana-Sinkam, S Patrick
Croce, Carlo M
author_sort Nana-Sinkam, S Patrick
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description In the past two decades, microRNAs have emerged as crucial mediators of organ development and human disease. Here, we discuss their role as drivers or suppressors of the hallmarks of cancer during tumorigenesis and progression, in defining interpatient heterogeneity and the promise of therapeutic application.
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spelling pubmed-47099982016-01-13 MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use Nana-Sinkam, S Patrick Croce, Carlo M Genome Biol Review In the past two decades, microRNAs have emerged as crucial mediators of organ development and human disease. Here, we discuss their role as drivers or suppressors of the hallmarks of cancer during tumorigenesis and progression, in defining interpatient heterogeneity and the promise of therapeutic application. BioMed Central 2014-08-31 2014 /pmc/articles/PMC4709998/ /pubmed/25315999 http://dx.doi.org/10.1186/s13059-014-0445-8 Text en © Nana-Sinkam and Croce; licensee BioMed Central Ltd. 2014 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Nana-Sinkam, S Patrick
Croce, Carlo M
MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use
title MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use
title_full MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use
title_fullStr MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use
title_full_unstemmed MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use
title_short MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use
title_sort microrna regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709998/
https://www.ncbi.nlm.nih.gov/pubmed/25315999
http://dx.doi.org/10.1186/s13059-014-0445-8
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