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Dendritic spine geometry can localize GTPase signaling in neurons

Dendritic spines are the postsynaptic terminals of most excitatory synapses in the mammalian brain. Learning and memory are associated with long-lasting structural remodeling of dendritic spines through an actin-mediated process regulated by the Rho-family GTPases RhoA, Rac, and Cdc42. These GTPases...

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Detalles Bibliográficos
Autores principales: Ramirez, Samuel A., Raghavachari, Sridhar, Lew, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710246/
https://www.ncbi.nlm.nih.gov/pubmed/26337387
http://dx.doi.org/10.1091/mbc.E15-06-0405