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Effect of methotrexate on rostral migratory stream in newborn rats

Two-day-old rats were treated with subcutaneous injections of methotrexate (MTX) 5 mg/kg and 150 mg/kg, and their rostral migratory streams (RMS) were examined time-dependently. MTX treatment increased pyknotic and TUNEL-positive cells and decreased mitotic and phospho-Histone H3-positive cells at a...

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Detalles Bibliográficos
Autores principales: HIRAKO, Ayano, SUN, Jin, FURUKAWA, Satoshi, TAKEUCHI, Takashi, SUGIYAMA, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710711/
https://www.ncbi.nlm.nih.gov/pubmed/26136044
http://dx.doi.org/10.1292/jvms.15-0280