Parameter Estimation of Ion Current Formulations Requires Hybrid Optimization Approach to Be Both Accurate and Reliable

Computational models of cardiac electrophysiology provided insights into arrhythmogenesis and paved the way toward tailored therapies in the last years. To fully leverage in silico models in future research, these models need to be adapted to reflect pathologies, genetic alterations, or pharmacologi...

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Detalles Bibliográficos
Autores principales: Loewe, Axel, Wilhelms, Mathias, Schmid, Jochen, Krause, Mathias J., Fischer, Fathima, Thomas, Dierk, Scholz, Eberhard P., Dössel, Olaf, Seemann, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710757/
https://www.ncbi.nlm.nih.gov/pubmed/26793704
http://dx.doi.org/10.3389/fbioe.2015.00209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710757/
https://www.ncbi.nlm.nih.gov/pubmed/26793704
http://dx.doi.org/10.3389/fbioe.2015.00209

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