Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

BACKGROUND: Microglia and macrophages play a central role in neuroinflammation. Pro-inflammatory cytokines trigger their conversion to a classically activated (M1) phenotype, sustaining inflammation and producing a cytotoxic environment. Conversely, anti-inflammatory cytokines polarize the cells tow...

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Detalles Bibliográficos
Autores principales: Ghosh, Mousumi, Xu, Yong, Pearse, Damien D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711034/
https://www.ncbi.nlm.nih.gov/pubmed/26757726
http://dx.doi.org/10.1186/s12974-015-0463-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711034/
https://www.ncbi.nlm.nih.gov/pubmed/26757726
http://dx.doi.org/10.1186/s12974-015-0463-9

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