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Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson’s disease

BACKGROUND: Mitochondrial dysfunction, oxidative stress and their interplay are core pathological features of Parkinson’s disease. In dopaminergic neurons, monoamines and their metabolites provide an additional source of reactive free radicals during their breakdown by monoamine oxidase or auto-oxid...

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Detalles Bibliográficos
Autores principales: Baranyi, Mária, Porceddu, Pier Francesca, Gölöncsér, Flóra, Kulcsár, Szabina, Otrokocsi, Lilla, Kittel, Ágnes, Pinna, Annalisa, Frau, Lucia, Huleatt, Paul B., Khoo, Mui-Ling, Chai, Christina L. L., Dunkel, Petra, Mátyus, Peter, Morelli, Micaela, Sperlágh, Beáta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711075/
https://www.ncbi.nlm.nih.gov/pubmed/26758813
http://dx.doi.org/10.1186/s13024-015-0067-y