Cargando…

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson’s disease

BACKGROUND: Mitochondrial dysfunction, oxidative stress and their interplay are core pathological features of Parkinson’s disease. In dopaminergic neurons, monoamines and their metabolites provide an additional source of reactive free radicals during their breakdown by monoamine oxidase or auto-oxid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baranyi, Mária, Porceddu, Pier Francesca, Gölöncsér, Flóra, Kulcsár, Szabina, Otrokocsi, Lilla, Kittel, Ágnes, Pinna, Annalisa, Frau, Lucia, Huleatt, Paul B., Khoo, Mui-Ling, Chai, Christina L. L., Dunkel, Petra, Mátyus, Peter, Morelli, Micaela, Sperlágh, Beáta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711075/ https://www.ncbi.nlm.nih.gov/pubmed/26758813 http://dx.doi.org/10.1186/s13024-015-0067-y

Ejemplares similares

Learned helplessness paradigm in P2xr7 wild type and knock out mice and its effect on synapses in the dentate gyrus
por: Otrokocsi, Lilla, et al.
Publicado: (2015)

Investigation of P2X7R involvement in maternal poly(i:C) exposure evoked autistic features in mice
por: Horváth, Gergely, et al.
Publicado: (2015)

P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression
por: Otrokocsi, Lilla, et al.
Publicado: (2017)

Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease
por: Hracskó, Zsuzsanna, et al.
Publicado: (2011)

The double-faced role of P2X(7) receptors in toxin-induced animal models of Parkinson’s disease
por: Sperlágh, Beáta, et al.
Publicado: (2011)

The antidepressant effect of short- and long-term zinc exposition is partly mediated by P2X7 receptors in male mice
por: Iring-Varga, Bernadett, et al.
Publicado: (2023)

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors
por: Csölle, Cecilia, et al.
Publicado: (2013)

Effect of genetic deletion and pharmacological antagonism of P2X7 receptors in a mouse animal model of migraine
por: Gölöncsér, Flóra, et al.
Publicado: (2014)

The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice
por: Csölle, Cecilia, et al.
Publicado: (2013)

Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice
por: Gölöncsér, Flóra, et al.
Publicado: (2017)

Solvent-free synthesis of propargylamines: an overview
por: Manujyothi, Ravi, et al.
Publicado: (2021)

The effects of optical, electrical and chemical stimulation on serotonin release from median raphe and hippocampus of mice
por: Goloncser, Flora, et al.
Publicado: (2015)

Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics
por: Wünsch, Matthias, et al.
Publicado: (2017)

Efficient Gold(I) Acyclic Diaminocarbenes for the Synthesis of Propargylamines and Indolizines
por: Aliaga-Lavrijsen, Mélanie, et al.
Publicado: (2018)

N-Propargylamines: versatile building blocks in the construction of thiazole cores
por: Arshadi, S, et al.
Publicado: (2017)

Metal-free multicomponent approach for the synthesis of propargylamine: a review
por: Ghosh, Sujit, et al.
Publicado: (2021)

Highly Selective Cyclization and Isomerization of Propargylamines to Access Functionalized Quinolines and 1-Azadienes
por: Wu, Zheng-Guang, et al.
Publicado: (2023)

Central P2Y(12) receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents
por: Horváth, Gergely, et al.
Publicado: (2014)

Modulation of dopaminergic neurotransmission in rat striatum upon in vitro and in vivo diclofenac treatment1
por: Milusheva, Elisaveta, et al.
Publicado: (2008)

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy
por: Marco-Contelles, José, et al.
Publicado: (2016)

The Asymmetric A(3)(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
por: Mo, Jia-Nan, et al.
Publicado: (2019)

Effect of storage on physical and functional properties of extracellular vesicles derived from neutrophilic granulocytes
por: Lőrincz, Ákos M., et al.
Publicado: (2014)

Neurochemical changes in animal models of Parkinson’s disease
por: Baranyi, Mária, et al.
Publicado: (2013)

Asymmetric synthesis of syn-propargylamines and unsaturated β-amino acids under Brønsted base catalysis
por: Wang, Yingcheng, et al.
Publicado: (2015)

Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism
por: Albreht, Alen, et al.
Publicado: (2018)

Gold nanoparticle decorated dithiocarbamate modified natural boehmite as a catalyst for the synthesis of biologically essential propargylamines
por: Zarenezhad, Elham, et al.
Publicado: (2022)

A low-nuclear Ag(4) nanocluster as a customized catalyst for the cyclization of propargylamine with CO(2)
por: Li, Lin, et al.
Publicado: (2023)

Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age
por: Costa, Giulia, et al.
Publicado: (2018)

Anchorage of Au(3+) into Modified Isoreticular Metal–Organic Framework-3 as a Heterogeneous Catalyst for the Synthesis of Propargylamines
por: Liu, Lili, et al.
Publicado: (2017)

Zn-Catalyzed Multicomponent KA(2) Coupling: One-Pot Assembly of Propargylamines Bearing Tetrasubstituted Carbon Centers
por: Tzouras, Nikolaos V., et al.
Publicado: (2019)

Base-Mediated Rearrangement of α-Dithioacetyl Propargylamines via Expansion of Dithioacetyl Ring: Synthesis of Medium-Sized S,S-Heterocycles
por: Dinc, Mert, et al.
Publicado: (2023)

Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age
por: Costa, Giulia, et al.
Publicado: (2019)

Immobilized Gold Nanoparticles Prepared from Gold(III)-Containing Ionic Liquids on Silica: Application to the Sustainable Synthesis of Propargylamines
por: Soengas, Raquel, et al.
Publicado: (2018)

Effect of the ortho-hydroxy group of salicylaldehyde in the A(3) coupling reaction: A metal-catalyst-free synthesis of propargylamine
por: Ghosh, Sujit, et al.
Publicado: (2017)

Recyclable Cu/C(3)N(4) composite catalyzed AHA/A(3) coupling reactions for the synthesis of propargylamines
por: Xu, Hang, et al.
Publicado: (2018)

Neurobiology of Parkinson’s Disease
por: Morelli, Micaela, et al.
Publicado: (2023)

Median raphe region stimulation alone generates remote, but not recent fear memory traces
por: Balázsfi, Diána G., et al.
Publicado: (2017)

Role of movement in long-term basal ganglia changes: implications for abnormal motor responses
por: Simola, Nicola, et al.
Publicado: (2013)

The role of P2X(7 )ATP receptors in the nervous system: potential implications in inflammatory and depression-like diseases
por: Csölle, Cecília, et al.
Publicado: (2009)

ZnCl(2) loaded TiO(2) nanomaterial: an efficient green catalyst to one-pot solvent-free synthesis of propargylamines
por: Bankar, Digambar B., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_fctugd420nb91e5mi7pspfif5l