Cargando…

L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice

New therapeutic modalities are needed for ovarian cancer, the most lethal gynecologic malignancy. Recent clinical trials have demonstrated the impressive therapeutic potential of adoptive therapy using chimeric antigen receptor (CAR)-redirected T cells to target hematological cancers, and emerging s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hong, Hao, Brown, Christine E., Ostberg, Julie R., Priceman, Saul J., Chang, Wen-Chung, Weng, Lihong, Lin, Paul, Wakabayashi, Mark T., Jensen, Michael C., Forman, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711972/ https://www.ncbi.nlm.nih.gov/pubmed/26761817 http://dx.doi.org/10.1371/journal.pone.0146885

Ejemplares similares

Novel Redirected T–Cell Immunotherapies for Advanced Prostate Cancer
por: Dorff, Tanya B., et al.
Publicado: (2022)

Development of HER2-specific chimeric antigen receptor T cells for the treatment of breast-to-brain metastasis
por: Priceman, Saul, et al.
Publicado: (2015)

Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells
por: Chmielewski, Markus, et al.
Publicado: (2013)

Development of chimeric antigen receptor-redirected T cell therapy targeting L1-CAM in ovarian cancer
por: Hong, Hao, et al.
Publicado: (2013)

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities
por: Van Caeneghem, Yasmine, et al.
Publicado: (2017)

Enhancing the antitumor potency of T cells redirected by bispecific antibodies
por: Chang, Chien-Hsing, et al.
Publicado: (2017)

Antigen-specific T cell redirectors (ATR) for antigen-specific redirection of T cells to tumors
por: Schütz, Christian, et al.
Publicado: (2014)

Development of chimeric antigen receptor (CAR) T-cell immunotherapy for glioblastoma targeting epidermal growth factor receptor variant III (EGFRvIII)
por: Park, Anthony K, et al.
Publicado: (2015)

Development and optimization of PSCA-specific CAR T cells for the treatment of bone metastatic prostate cancer
por: Gerdts, Ethan, et al.
Publicado: (2015)

Redirection to the bone marrow improves T cell persistence and antitumor functions
por: Khan, Anjum B., et al.
Publicado: (2018)

Redirected Primary Human Chimeric Antigen Receptor Natural Killer Cells As an “Off-the-Shelf Immunotherapy” for Improvement in Cancer Treatment
por: Oberschmidt, Olaf, et al.
Publicado: (2017)

Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor
por: Zhang, Ge, et al.
Publicado: (2014)

Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer
por: Reppel, Loïc, et al.
Publicado: (2022)

Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells
por: Schütz, Christian, et al.
Publicado: (2016)

Bispecific T-Cell Redirection versus Chimeric Antigen Receptor (CAR)-T Cells as Approaches to Kill Cancer Cells
por: Strohl, William R., et al.
Publicado: (2019)

B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres
por: Nehama, Dean, et al.
Publicado: (2019)

Correction: Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells
por: Schütz, Christian, et al.
Publicado: (2018)

Engineering Immune Cells for in vivo Secretion of Tumor-Specific T Cell-Redirecting Bispecific Antibodies
por: Blanco, Belén, et al.
Publicado: (2020)

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines
por: Junttila, Ilkka S., et al.
Publicado: (2012)

Fully human CD19-specific chimeric antigen receptors for T-cell therapy
por: Sommermeyer, Daniel, et al.
Publicado: (2017)

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain
Publicado: (1993)

Potential of chimeric antigen receptor (CAR)‐redirected immune cells in breast cancer therapies: Recent advances
por: Nikoo, Marzieh, et al.
Publicado: (2022)

NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma
por: Murayama, Yudai, et al.
Publicado: (2022)

Efficient Selection of Genetically Modified Human T Cells Using Methotrexate-Resistant Human Dihydrofolate Reductase
por: Jonnalagadda, Mahesh, et al.
Publicado: (2013)

Suicide Gene Therapy to Increase the Safety of Chimeric Antigen Receptor-Redirected T Lymphocytes
por: Casucci, Monica, et al.
Publicado: (2011)

Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection
por: Albers, Julian J, et al.
Publicado: (2019)

A cisplatin conjugate with tumor cell specificity exhibits antitumor effects in renal cancer models
por: Mrdenovic, Stefan, et al.
Publicado: (2023)

Chimeric Antigen Receptor-Modified T Cells Redirected to EphA2 for the Immunotherapy of Non-Small Cell Lung Cancer
por: Li, Ning, et al.
Publicado: (2017)

Engineering Human T Cells for Resistance to Methotrexate and Mycophenolate Mofetil as an In Vivo Cell Selection Strategy
por: Jonnalagadda, Mahesh, et al.
Publicado: (2013)

Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of V(L) and V(H) Domains Targeting CD123(+) Tumors
por: Thokala, Radhika, et al.
Publicado: (2016)

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T-lymphocytes
por: Caruana, Ignazio, et al.
Publicado: (2015)

Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma
por: Skuljec, Jelena, et al.
Publicado: (2017)

VEGFR2-specific FnCAR effectively redirects the cytotoxic activity of T cells and YT NK cells
por: Kulemzin, Sergey V., et al.
Publicado: (2018)

CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells
por: Blomquist, Thomas M., et al.
Publicado: (2013)

Rapid, site-specific labeling of “off-the-shelf” and native serum autoantibodies with T cell–redirecting domains
por: Zappala, Fabiana, et al.
Publicado: (2022)

Conduit CAR: Redirecting CAR T-Cell Specificity with A Universal and Adaptable Bispecific Antibody Platform
por: Borrok, M. Jack, et al.
Publicado: (2022)

DCs redirect T cell traffic
por: Van Epps, Heather L.
Publicado: (2005)

Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein
por: Sautto, Giuseppe A, et al.
Publicado: (2016)

AN ASSAY FOR INTERCELLULAR ADHESIVE SPECIFICITY
por: Roth, Stephen, et al.
Publicado: (1971)

The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors
por: Guerrero, Alan D, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6oj820rcmflkjlfgorb3v8rcgt