Multiple protein–protein interactions converging on the Prp38 protein during activation of the human spliceosome

Spliceosomal Prp38 proteins contain a conserved amino-terminal domain, but only higher eukaryotic orthologs also harbor a carboxy-terminal RS domain, a hallmark of splicing regulatory SR proteins. We show by crystal structure analysis that the amino-terminal domain of human Prp38 is organized around...

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Detalles Bibliográficos
Autores principales: Schütze, Tonio, Ulrich, Alexander K.C., Apelt, Luise, Will, Cindy L., Bartlick, Natascha, Seeger, Martin, Weber, Gert, Lührmann, Reinhard, Stelzl, Ulrich, Wahl, Markus C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712676/
https://www.ncbi.nlm.nih.gov/pubmed/26673105
http://dx.doi.org/10.1261/rna.054296.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712676/
https://www.ncbi.nlm.nih.gov/pubmed/26673105
http://dx.doi.org/10.1261/rna.054296.115

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