1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter

Effector CD8(+) T cells convert from IFN-γ(+) (Tc1) to IL-13(+) (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined. Here, we show that addition of 1,25D3, the active form of vitamin D3, during CD8(+) T-cell differentiation prevents IL-4-induced conversion to...

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Detalles Bibliográficos
Autores principales: Schedel, Michaela, Jia, Yi, Michel, Sven, Takeda, Katsuyuki, Domenico, Joanne, Joetham, Anthony, Ning, Fangkun, Strand, Matthew, Han, Junyan, Wang, Meiqin, Lucas, Joseph J., Vogelberg, Christian, Kabesch, Michael, O'Connor, Brian P., Gelfand, Erwin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712703/
https://www.ncbi.nlm.nih.gov/pubmed/26750596
http://dx.doi.org/10.1038/ncomms10213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712703/
https://www.ncbi.nlm.nih.gov/pubmed/26750596
http://dx.doi.org/10.1038/ncomms10213

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