ERAD of proteins containing aberrant transmembrane domains requires ubiquitylation of cytoplasmic lysine residues

Clearance of misfolded proteins from the endoplasmic reticulum (ER) is mediated by the ubiquitin-proteasome system in a process known as ER-associated degradation (ERAD). The mechanisms through which proteins containing aberrant transmembrane domains are degraded by ERAD are poorly understood. To ad...

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Detalles Bibliográficos
Autores principales: Briant, Kit, Koay, Yee-Hui, Otsuka, Yuka, Swanton, Eileithyia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712780/
https://www.ncbi.nlm.nih.gov/pubmed/26446255
http://dx.doi.org/10.1242/jcs.171215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712780/
https://www.ncbi.nlm.nih.gov/pubmed/26446255
http://dx.doi.org/10.1242/jcs.171215

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