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ERAD of proteins containing aberrant transmembrane domains requires ubiquitylation of cytoplasmic lysine residues
Clearance of misfolded proteins from the endoplasmic reticulum (ER) is mediated by the ubiquitin-proteasome system in a process known as ER-associated degradation (ERAD). The mechanisms through which proteins containing aberrant transmembrane domains are degraded by ERAD are poorly understood. To ad...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712780/ https://www.ncbi.nlm.nih.gov/pubmed/26446255 http://dx.doi.org/10.1242/jcs.171215 |