Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation

Circumstances that compromise efficient DNA replication, such as disruptions to replication fork progression, cause a state known as DNA replication stress (RS). Whereas normally proliferating cells experience low levels of RS, excessive RS from intrinsic or extrinsic sources can trigger cell cycle...

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Detalles Bibliográficos
Autores principales: Bai, Gongshi, Smolka, Marcus B., Schimenti, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713100/
https://www.ncbi.nlm.nih.gov/pubmed/26765334
http://dx.doi.org/10.1371/journal.pgen.1005787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713100/
https://www.ncbi.nlm.nih.gov/pubmed/26765334
http://dx.doi.org/10.1371/journal.pgen.1005787

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