P1 Ref Endonuclease: A Molecular Mechanism for Phage-Enhanced Antibiotic Lethality

Ref is an HNH superfamily endonuclease that only cleaves DNA to which RecA protein is bound. The enigmatic physiological function of this unusual enzyme is defined here. Lysogenization by bacteriophage P1 renders E. coli more sensitive to the DNA-damaging antibiotic ciprofloxacin, an example of a ph...

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Detalles Bibliográficos
Autores principales: Ronayne, Erin A., Wan, Y. C. Serena, Boudreau, Beth A., Landick, Robert, Cox, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713147/
https://www.ncbi.nlm.nih.gov/pubmed/26765929
http://dx.doi.org/10.1371/journal.pgen.1005797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713147/
https://www.ncbi.nlm.nih.gov/pubmed/26765929
http://dx.doi.org/10.1371/journal.pgen.1005797

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