TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

Monocyte phenotype and output changes with age, but why this occurs and how it impacts anti-bacterial immunity are not clear. We found that, in both humans and mice, circulating monocyte phenotype and function was altered with age due to increasing levels of TNF in the circulation that occur as part...

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Detalles Bibliográficos
Autores principales: Puchta, Alicja, Naidoo, Avee, Verschoor, Chris P., Loukov, Dessi, Thevaranjan, Netusha, Mandur, Talveer S., Nguyen, Phuong-son, Jordana, Manel, Loeb, Mark, Xing, Zhou, Kobzik, Lester, Larché, Maggie J., Bowdish, Dawn M. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713203/
https://www.ncbi.nlm.nih.gov/pubmed/26766566
http://dx.doi.org/10.1371/journal.ppat.1005368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713203/
https://www.ncbi.nlm.nih.gov/pubmed/26766566
http://dx.doi.org/10.1371/journal.ppat.1005368

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