Cargando…

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

Monocyte phenotype and output changes with age, but why this occurs and how it impacts anti-bacterial immunity are not clear. We found that, in both humans and mice, circulating monocyte phenotype and function was altered with age due to increasing levels of TNF in the circulation that occur as part...

Descripción completa

Detalles Bibliográficos
Autores principales:	Puchta, Alicja, Naidoo, Avee, Verschoor, Chris P., Loukov, Dessi, Thevaranjan, Netusha, Mandur, Talveer S., Nguyen, Phuong-son, Jordana, Manel, Loeb, Mark, Xing, Zhou, Kobzik, Lester, Larché, Maggie J., Bowdish, Dawn M. E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713203/ https://www.ncbi.nlm.nih.gov/pubmed/26766566 http://dx.doi.org/10.1371/journal.ppat.1005368

Ejemplares similares

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction
por: Thevaranjan, Netusha, et al.
Publicado: (2018)

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction
por: Thevaranjan, Netusha, et al.
Publicado: (2017)

TNF, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity‐induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice
por: Breznik, Jessica A., et al.
Publicado: (2018)

6 Incidence of Eating Disorders During COVID-19: A Retrospective Review
por: Thevaranjan, Netusha, et al.
Publicado: (2022)

IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity
por: Karimi, Yalda, et al.
Publicado: (2019)

Delayed Therapy with Plasma Gelsolin Improves Survival in Murine Pneumococcal Pneumonia
por: Yang, Zhiping, et al.
Publicado: (2017)

Estimating SARS-CoV-2 seroprevalence in long-term care: a window of opportunity
por: Verschoor, Chris P, et al.
Publicado: (2022)

Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity
por: Jiménez-Saiz, Rodrigo, et al.
Publicado: (2020)

Acute organ injury and long-term sequelae of severe pneumococcal infections
por: Kruckow, Katherine L., et al.
Publicado: (2023)

The Scavenger Receptor MARCO Is Required for Lung Defense against Pneumococcal Pneumonia and Inhaled Particles
por: Arredouani, Mohamed, et al.
Publicado: (2004)

Alterations to the Frequency and Function of Peripheral Blood Monocytes and Associations with Chronic Disease in the Advanced-Age, Frail Elderly
por: Verschoor, Chris P., et al.
Publicado: (2014)

Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study
por: Lamarche, Daphnée, et al.
Publicado: (2018)

Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children
por: Verschoor, Chris P., et al.
Publicado: (2015)

Correction: Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children
por: Verschoor, Chris P., et al.
Publicado: (2016)

Mycoplasma pneumoniae, a trigger for Weston Hurst syndrome
por: Magun, Rick, et al.
Publicado: (2016)

The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by Age
por: Lelic, Alina, et al.
Publicado: (2012)

Curcumin Can Decrease Tissue Inflammation and the Severity of HSV-2 Infection in the Female Reproductive Mucosa
por: Vitali, Danielle, et al.
Publicado: (2020)

Host cytokine responses distinguish invasive from airway isolates of the Streptococcusmilleri/anginosis group
por: Kaiser, Julienne C, et al.
Publicado: (2014)

An Introduction to Automated Flow Cytometry Gating Tools and Their Implementation
por: Verschoor, Chris P., et al.
Publicado: (2015)

Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer
por: Verschoor, Chris P., et al.
Publicado: (2013)

Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis
por: Hayes, Christina L., et al.
Publicado: (2018)

Transplacental Passage of Interleukins 4 and 13?
por: Lim, Robert H., et al.
Publicado: (2009)

Characterization of immortalized MARCO and SR-AI/II-deficient murine alveolar macrophage cell lines
por: Zhou, Hongwei, et al.
Publicado: (2008)

Characterising Pre-pubertal Resistance to Death from Endotoxemia
por: Joachim, Rose, et al.
Publicado: (2017)

Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα–dependent but microbiota-independent tertiary lymphoid tissue formation
por: Ligon, Marianne M., et al.
Publicado: (2020)

The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study
por: Verschoor, Chris P., et al.
Publicado: (2017)

Persistence of Pneumococcal Serotype 3 in Adult Pneumococcal Disease in Hong Kong
por: Subramanian, Reema, et al.
Publicado: (2021)

Myeloid-derived suppressor cells, age and cancer
por: Bowdish, Dawn ME
Publicado: (2013)

Risk for Asthma in Offspring of Asthmatic Mothers versus Fathers: A Meta-Analysis
por: Lim, Robert H., et al.
Publicado: (2010)

Scavenger receptors and β-glucan receptors participate in the recognition of yeasts by murine macrophages
por: Józefowski, Szczepan, et al.
Publicado: (2011)

Prediction of clinical peanut allergy status among children in Hamilton, Ontario using chart review data collected during 2012–2015
por: Simms, Elizabeth, et al.
Publicado: (2017)

Link between Epigenomic Alterations and Genome-Wide Aberrant Transcriptional Response to Allergen in Dendritic Cells Conveying Maternal Asthma Risk
por: Mikhaylova, Lyudmila, et al.
Publicado: (2013)

TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice
por: Steinwede, Kathrin, et al.
Publicado: (2012)

Predictors of pneumococcal vaccination among older adults with pneumonia: findings from the Community Acquired Pneumonia Impact Study
por: Krueger, Paul, et al.
Publicado: (2010)

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo
por: Chu, Derek K., et al.
Publicado: (2014)

The impact of respiratory infections and probiotic use on the nasal microbiota of frail residents in long-term care homes
por: Bowdish, Dawn M.E., et al.
Publicado: (2023)

Pneumococcal pneumonia on the job: Uncovering the past story of occupational exposure to metal fumes and dust
por: Torén, Kjell, et al.
Publicado: (2022)

New perspectives on immunological pathways underlying peanut-induced anaphylaxis
por: Jordana, Manel
Publicado: (2011)

Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
por: Kennedy, Allison E., et al.
Publicado: (2021)

Maternal allergic contact dermatitis causes increased asthma risk in offspring
por: Lim, Robert H, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_c32co0ad16hdva5cq311nch70a