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Methylation quantitative trait loci in the developing brain and their enrichment in schizophrenia-associated genomic regions
We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n=166) of human fetal brain samples spanning 56–166 days post-conception, identifying >16,000 fetal brain mQTLs. Fetal brain mQTLs are primarily cis-acting, enriched in regulatory chromatin domains and transcr...
Autores principales: | Hannon, Eilis, Spiers, Helen, Viana, Joana, Pidsley, Ruth, Burrage, Joe, Murphy, Therese M, Troakes, Claire, Turecki, Gustavo, O’Donovan, Michael C., Schalkwyk, Leonard C., Bray, Nicholas J., Mill, Jonathan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714325/ https://www.ncbi.nlm.nih.gov/pubmed/26619357 http://dx.doi.org/10.1038/nn.4182 |
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