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Identification and spontaneous immune targeting of an endogenous retrovirus K envelope protein in the Indian rhesus macaque model of human disease

BACKGROUND: Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections that have invaded the germ line of both humans and non-human primates. Most ERVs are functionally crippled by deletions, mutations, and hypermethylation, leading to the view that they are inert genomic fossils....

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Detalles Bibliográficos
Autores principales: Wu, Helen L., Léon, Enrique J., Wallace, Lyle T., Nimiyongskul, Francesca A., Buechler, Matthew B., Newman, Laura P., Castrovinci, Philip A., Paul Johnson, R., Gifford, Robert J., Brad Jones, R., Sacha, Jonah B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714462/
https://www.ncbi.nlm.nih.gov/pubmed/26767784
http://dx.doi.org/10.1186/s12977-016-0238-0