Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial

BACKGROUND: Several small studies indicated that the genotype of KIT or platelet-derived growth factor receptor-α (PDGFRA) contributes in part to the level of clinical effectiveness of sunitinib in gastrointestinal stromal tumor (GIST) patients. This study aimed to correlate KIT and PDGFRA mutationa...

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Detalles Bibliográficos
Autores principales: Reichardt, Peter, Demetri, George D., Gelderblom, Hans, Rutkowski, Piotr, Im, Seock-Ah, Gupta, Sudeep, Kang, Yoon-Koo, Schöffski, Patrick, Schuette, Jochen, Soulières, Denis, Blay, Jean-Yves, Goldstein, David, Fly, Kolette, Huang, Xin, Corsaro, Massimo, Lechuga, Maria Jose, Martini, Jean-Francois, Heinrich, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714485/
https://www.ncbi.nlm.nih.gov/pubmed/26772734
http://dx.doi.org/10.1186/s12885-016-2051-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714485/
https://www.ncbi.nlm.nih.gov/pubmed/26772734
http://dx.doi.org/10.1186/s12885-016-2051-5

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