Safety and biodistribution assessment of sc-rAAV2.5IL-1Ra administered via intra-articular injection in a mono-iodoacetate-induced osteoarthritis rat model

Interleukin-1 (IL-1) plays an important role in the pathophysiology of osteoarthritis (OA), and gene transfer of IL-1 receptor antagonist (IL-1Ra) holds promise for OA treatment. A preclinical safety and biodistribution study evaluated a self-complementary adeno-associated viral vector carrying rat...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Gensheng, Evans, Christopher H, Benson, Janet M, Hutt, Julie A, Seagrave, JeanClare, Wilder, Julie A, Grieger, Joshua C, Samulski, R Jude, Terse, Pramod S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714526/
https://www.ncbi.nlm.nih.gov/pubmed/26817025
http://dx.doi.org/10.1038/mtm.2015.52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714526/
https://www.ncbi.nlm.nih.gov/pubmed/26817025
http://dx.doi.org/10.1038/mtm.2015.52

Ejemplares similares