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Transforming growth factor‐β signaling enhancement by long‐term exposure to hypoxia in a tumor microenvironment composed of Lewis lung carcinoma cells

Transforming growth factor‐β (TGF‐β) is a potent growth inhibitor in normal epithelial cells. However, a number of malignant tumors produce excessive amounts of TGF‐β, which affects the tumor‐associated microenvironment by furthering the progression of tumorigenicity. Although it is known that the t...

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Detalles Bibliográficos
Autores principales: Furuta, Chiaki, Miyamoto, Tatsuki, Takagi, Takahiro, Noguchi, Yuri, Kaneko, Jyunya, Itoh, Susumu, Watanabe, Takuya, Itoh, Fumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714699/
https://www.ncbi.nlm.nih.gov/pubmed/26296946
http://dx.doi.org/10.1111/cas.12773