Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

Impaired function of NPC1 or NPC2 lysosomal proteins leads to the intracellular accumulation of unesterified cholesterol, the primary defect underlying Niemann-Pick type C (NPC) disease. In addition, glycosphingolipids (GSLs) accumulate in lysosomes as well. Intralysosomal lipid accumulation trigger...

Descripción completa

Detalles Bibliográficos
Autores principales: Marques, André R. A., Gabriel, Tanit L., Aten, Jan, van Roomen, Cindy P. A. A., Ottenhoff, Roelof, Claessen, Nike, Alfonso, Pilar, Irún, Pilar, Giraldo, Pilar, Aerts, Johannes M. F. G., van Eijk, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714856/
https://www.ncbi.nlm.nih.gov/pubmed/26771826
http://dx.doi.org/10.1371/journal.pone.0147208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714856/
https://www.ncbi.nlm.nih.gov/pubmed/26771826
http://dx.doi.org/10.1371/journal.pone.0147208

Ejemplares similares