Cargando…

Leucine‐rich repeat kinase 2 interacts with p21‐activated kinase 6 to control neurite complexity in mammalian brain

Leucine‐rich repeat kinase 2 (LRRK2) is a causative gene for Parkinson's disease, but the physiological function and the mechanism(s) by which the cellular activity of LRRK2 is regulated are poorly understood. Here, we identified p21‐activated kinase 6 (PAK6) as a novel interactor of the GTPase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Civiero, Laura, Cirnaru, Maria Daniela, Beilina, Alexandra, Rodella, Umberto, Russo, Isabella, Belluzzi, Elisa, Lobbestael, Evy, Reyniers, Lauran, Hondhamuni, Geshanthi, Lewis, Patrick A., Van den Haute, Chris, Baekelandt, Veerle, Bandopadhyay, Rina, Bubacco, Luigi, Piccoli, Giovanni, Cookson, Mark R., Taymans, Jean‐Marc, Greggio, Elisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715492/ https://www.ncbi.nlm.nih.gov/pubmed/26375402 http://dx.doi.org/10.1111/jnc.13369

Ejemplares similares

Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers
por: Civiero, Laura, et al.
Publicado: (2012)

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
por: Lobbestael, E., et al.
Publicado: (2016)

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
por: Taymans, Jean-Marc, et al.
Publicado: (2011)

Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
por: Greggio, Elisa, et al.
Publicado: (2011)

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2
por: Civiero, Laura, et al.
Publicado: (2017)

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity
por: Lobbestael, Evy, et al.
Publicado: (2020)

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
por: Iannotta, Lucia, et al.
Publicado: (2020)

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4
por: Russo, Isabella, et al.
Publicado: (2018)

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
por: Cirnaru, Maria D., et al.
Publicado: (2014)

Leucine-rich repeat kinase 2 mutations and Parkinson’s disease: three questions
por: Greggio, Elisa, et al.
Publicado: (2009)

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate
por: Belluzzi, Elisa, et al.
Publicado: (2016)

LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson’s Disease, Where Do We Stand?
por: Taymans, Jean-Marc, et al.
Publicado: (2016)

Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?
por: Greggio, Elisa, et al.
Publicado: (2012)

Ceramides in Parkinson’s Disease: From Recent Evidence to New Hypotheses
por: Plotegher, Nicoletta, et al.
Publicado: (2019)

The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation
por: Kumar, Azad, et al.
Publicado: (2010)

Immunohistochemical detection of transgene expression in the brain using small epitope tags
por: Lobbestael, Evy, et al.
Publicado: (2010)

Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
por: Russo, Isabella, et al.
Publicado: (2015)

GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1
por: Jebelli, Joseph D., et al.
Publicado: (2012)

Erratum to: Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
por: Russo, Isabella, et al.
Publicado: (2016)

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase–mediated centrosomal cohesion and ciliogenesis deficits
por: Lara Ordónez, Antonio Jesús, et al.
Publicado: (2019)

LRRK2 modulates neuronal vesicles cycle through protein interactions
por: Piccoli, Giovanni, et al.
Publicado: (2015)

Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization
por: De Wit, T., et al.
Publicado: (2018)

Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution
por: Mamais, Adamantios, et al.
Publicado: (2014)

A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation
por: Law, Bernard M. H., et al.
Publicado: (2014)

Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation
por: Filograna, Roberta, et al.
Publicado: (2015)

Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases
por: Taymans, Jean-Marc, et al.
Publicado: (2014)

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
por: Madero-Pérez, Jesús, et al.
Publicado: (2018)

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation
por: Cabezudo, Diego, et al.
Publicado: (2020)

GTP binding controls complex formation by the human ROCO protein MASL1
por: Dihanich, Sybille, et al.
Publicado: (2014)

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2
por: Vancraenenbroeck, Renée, et al.
Publicado: (2014)

ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization
por: Si, Jianmin, et al.
Publicado: (2021)

Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson’s Disease and Multiple System Atrophy
por: Sonustun, Berkiye, et al.
Publicado: (2022)

α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells
por: Bisaglia, Marco, et al.
Publicado: (2010)

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions
por: Obergasteiger, Julia, et al.
Publicado: (2020)

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?
por: Russo, Isabella, et al.
Publicado: (2014)

Genetic, Structural, and Molecular Insights into the Function of Ras of Complex Proteins Domains
por: Civiero, Laura, et al.
Publicado: (2014)

Editorial: The Role of Lipids in the Pathogenesis of Parkinson's Disease
por: Baekelandt, Veerle, et al.
Publicado: (2020)

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease
por: Iovino, Ludovica, et al.
Publicado: (2022)

LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
por: Kedariti, Maria, et al.
Publicado: (2022)

The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology
por: Obergasteiger, Julia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_45f1rlvi1q4pvpip3ci81s9uls