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Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

Ferroptosis is a form of regulated non-apoptotic cell death that has been implicated in several disease contexts. A better understanding of the ferroptotic death mechanism could lead to the development of new therapeutics for degenerative diseases, and a better understanding of how to induce ferropt...

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Detalles Bibliográficos
Autores principales: Hayano, M, Yang, W S, Corn, C K, Pagano, N C, Stockwell, B R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716307/
https://www.ncbi.nlm.nih.gov/pubmed/26184909
http://dx.doi.org/10.1038/cdd.2015.93